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Despite their importance, trial registries and results databases have several limitations. Firstly, there is https://www.pinisibakerynyc.com no universal mechanism for ensuring adherence to standards for registration or results disclosure, meaning that not all trials will be captured. Journal policy will be ineffective for trials that are not intended for publication, while current legislation does not pertain to procedural, educational, and other unregulated interventions. Secondly, the quality of registered information is highly variable and often uninformative.7 10 11 12 13 Changes to registered information are common,12 meaning that systematic reviewers should review the history of amendments for each registry record. Thirdly, even when a trial is fully registered with complete summary results presented, there is a limited amount of methodological information available that is largely inadequate for assessing the risk of bias.10 This concern would be addressed if full protocols were made available on the registries.9 14 Finally, most trials will not have been registered prior to the introduction of International Committee of Medical Journal Editors policy and WHO standards in 2005. have access to substantially more clinical trial Kamagra Viagra
information than the healthcare providers, patients, and researchers who use and evaluate the interventions. Successful attempts to obtain access to regulatory data have previously necessitated litigation and incurred lengthy delays.15 16 17 Over recent years, regulatory agencies have recognised the need to address this untenable situation by increasing public access to information from regulatory submissions.18 19